Saad Sami AlSogair
Managing Director, Elite Derma Care Center, Saudi Arabia
Title: Anti-Aging Potentials of Methylene Blue for Human Skin
Biography
Biography: Saad Sami AlSogair
Abstract
Skin is the largest and the most visible organ of the human body. Aged skin is biologically characterized by the flattening of the dermal-epidermal junction, general atrophy of the extracellular matrix (ECM) and disorganized and reduced collagen and elastin. Skin aging can be delayed by external application to suppress production of free radicals or to neutralize excess free radicals. Methylene blue is a century-old drug has potent antibiotic and antioxidant properties and has the ability to suppress production of superoxide radicals. It acts as an alternative receptor of xanthine oxide electrons and has received increased attention due to its usefulness in treating mitochondrial dysfunction. MB at nanomolar concentration has been found to be potent in scavenging free radicals and stimulate cell proliferation in both young and old dermal fibroblasts. MB treatment on 3D reconstructed skin models provides strong evidence of its potential for improving skin viability, increasing skin hydration and thickness, promoting skin elastin and collagen synthesis, and protecting the skin matrix through the inhibition of enzymatic degradation by MMP. Altogether, this presentation suggests that MB can be a promising agent for use in anti-aging cosmetics.