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Maria-Eleni Paroikaki

Imperial College London, London

Title: Cutaneous complications of MRNA and AZD1222 covid-19 vaccines: A worldwide review

Biography

Biography: Maria-Eleni Paroikaki

Abstract

Aim
Due to the rising cases of cutaneous reactions that are observed worldwide following COVID-19 vaccinations, the aim of this study is to investigate the cutaneous complication  that occur following mRNA-1273 (Moderna), BNT162b2 (Pfizer-BioNTech) and AZD1222 (AstraAzeneca-Oxford University) vaccination, through the already published reports. 
Material
Material was gathered from the already published reports regarding the cutaneous complications of the above vaccines, published until September 30, 2021. The search was conducted in the PubMed, Google scholar and Scopus databases, as well as in the preprint server bioRxiv. The review includes eighty studies that describe a total of 1415 complications. 
Results
More cutaneous reactions were observed in women (81.6%). The most common complication was delayed large local reactions (40.4%), followed by local injection site reactions (16.5%), zoster (9.5%), and urticarial eruptions (9.0%). Injection site and delayed large local reactions were predominantly caused by the mRNA-1273 vaccine (79.5% and 72.0%, respectively). BNT162b2 vaccination was linked to distant reactions (50.1%) more than
mRNA-1273 (30.0%). The most common distant reaction was Zoster. Of reactions with adequate information for both vaccine doses, 58.3% occurred only after the first, 26.9% only after the second, and 14.8% after both doses.
Conclusion
Overall, a large spectrum of cutaneous reactions occurred following the COVID-19 vaccination. Most were mild and without long-term health implications. Therefore, it appears like such dermatologic complications do not contraindicate subsequent vaccination.