22^nd World Dermatology Congress September 27-28, 2021 Tokyo, Japan

Biography:

Dr. Natasa Tsekova is head of Department of Oncodermatology and Dermatosurgery in University Hospital of Oncology, Sofia- Bulgaria. Her area of emphasis are skin cancer- diagnostic and treatment, dermatosurgery and adverse reaction during systemic treatment in cancer patients.  She published her works in numerous national and international journals. Аlso participates in various international conferences and trainings in order to make the acquired knowledge and practices useful for patients and shared with colleagues. Dr. Tsekova makes great efforts to apply all modern diagnostic and treatment methods in oncodermatological practice and make them accessible for patients in Bulgaria.

Abstract:

Differentiation of pigmented skin lesions, benign and malignant, is not a difficult approach and can be done only with a clinical examination by an experienced dermatologist. Proper and fast diagnosis is essential because it can increase patient survival, especially in malignant melanoma. In recent decades, dermatoscopy has developed to a state-of-the-art method for evaluating pigmented skin lesions and following well-defined criteria helps the confirmation of diagnosis.

Sometimes diagnosis of  pigmented lesions is a challenge, especially when the lesions are localized on the palmoplantar surface, nail matrix, or occur in children. For patients with large congenital melanocytic nevi, the risk of developing melanoma (cutaneous or extracutaneous) is estimated to be 5–10% over a lifetime, with approximately half of this risk during the first 5 years of life. Nevi that involve the nail matrix can present as longitudinal melanonychia, a tan, brown or black streak caused by increased melanin deposition in the nail plate. Although streaks that develop in childhood are usually benign, single bands that are dark in color or wide (6 mm), become darker or wider with time, are associated with nail dystrophy, or have extension of pigmentation beyond the nail fold warrant biopsy of the nail matrix to exclude melanoma. Sometimes difficult in practice is the diagnosis of Spitz nevi. Spitz nevi are benign, usually acquired proliferations of melanocytes with histopathologic features that sometimes overlap with those of melanoma. Therefore, proper diagnosis is essential.

Just as the evaluation of skin lesions at special anatomical sites can be demanding, some melanoma subtypes are particularly challenging to diagnose.

To avoid unnecessary worry, dermatologist need to be aware of the natural history and clinical spectrum of melanocytic nevi as well as features of pigmented lesions and patient phenotypes that should raise concern.

Biography:

Dr. Christeen Youssef graduated with a degree of Bachelor of Medicine and Surgery and subsequently taken her Master of Science in Dermatology and Venereology from the reputable Zagazig University in Egypt. Her dedication to Dermatology and Aesthetic Medicine continuously inspires young doctors as she shares her expertise as an Associate Professor of Dermatology in the same institution since 2005 till present. As well respected Aesthetic and Dermatology Specialist in the UAE and abroad, Dr. Christeen Youssef is an advocate of true clinical results through safe and scientifically proven medical practice.

Abstract:

Cutaneous fibrosis or Scars develop as a result of suboptimal wound healing after serious tissue injuries such as extreme burns, trauma, and major surgery leading to prolonged inflammatory responses and pathological fibroproliferative responses in wounds.

The latest studies have investigated molecular regulators at each phase of wound healing: inflammation, proliferation, and remodelling phases.

Here we reviewed the current literature that illustrate molecular pathways for one of the novel methods for scarless wound healing which is Stromal Vascular Fraction (SVF). SVF contains a large population of stem cells called adipose-derived stem cells (ADSCs), that share a number of similarities with bone marrow stem cells, including the capacity for multilineage differentiation.

Scar tissue consists mainly of myofibroblasts formed by fibrillar collagen. Factors that are essential for myofibroblast activation include the availability of active growth factors such as TGFβ1 and PDGF; activation of inflammatory signaling; and mechanical response to stress. Results of studies have been done on animals showed that collagen in the group that had SVF was arranged more regularly with a broader gap between collagens. And also the mRNA expressions of TGF-β and Smad3 in the SVF group were significantly down-regulated. another experiment showed that SVF contains EGF and VEGF cytokines which enhance the ability of keratinocyte cells to migrate and proliferate cells and have obvious effects on depressed scars for clinical use. Trials have been done on human showed also a huge improvement and significant increase in scar tissue score for all the patient who had the SVF injection.

Biography:

She is the Director and Founder Possitive Vibes. 

Abstract:

Background: Consideration of psychiatric and psychosocial factors is important for the management and prevention of dermatologic disorders. Dermatology patients suffer commonly from psychiatric  comorbidity.

Aim:To study pattern and prevalence of psychiatric disorders among patient attending dermatology OPD .

Methods: The study was carried out in Psychiatry department of NIMS Medical college, Jaipur, Rajasthan, a north State of India. The sample was taken from Dermatology department of Medical College. All the participants were diagnosed/confirmed cases of skin. Socio-demographic data was collected .Patients scoring more than 12 on GHQ were examined for presence of psychiatric illness. Patients so identified were administered Indian Psychiatric Interview Schedule (IPIS) to asses profile of psychiatric symptoms in detail. Diagnosis were derived from symptom clusters elicited by IPIS according to International Classification of disease –tenth revision (ICD-10). 

Findings: As per ICD-10 diagnosis 34.2% of total sample were diagnosed with definite Psychiatric comorbidity. Maximum number of cases were of Depression 36.32% (N=146) followed by Anxiety disorder 18.41% (74) and 7.96% (N=32) with Somatoform disorder. Obsessive compulsive disorder was diagnosed in 6.47% (N=26) followed by Adjustment disorder 4.98% (N=20) and Alcohol dependency 4.98% (N=20). Minimum number of cases belonged to Schizophrenia 2.99% (N=12) and Bipolar Affective disorder 2.99% (N=12). No diagnosis was found in 14.93% (N=60).

Conclusion: Significant psychiatric comorbidity exist in patients of dermatology. Biopsychosocial approach to patients with skin disease should be sought by liaison between psychiatrist and dermatologist.

Biography:

Nayrah S. Attia has completed her M.B.B.Ch at the age of 23 years from Faculty of medicine – Cairo University, Egypt. She is completing her Master's degree from Faculty of medicine – Menoufia University, Egypt. She is working resident dermatology at Egyptian ministry of health.

Abstract:

Leprosy is a chronic infectious disease with many risk factors including food shortage which leads to nutritional deficiencies that may affect the immune system and influence the progression of leprosy. We elucidate the relation between the serum level of zinc, vit C and selenium and the clinical spectrum of leprosy. This case control study included 100 leprotic   patients (50 multibacillary-50 paucibacillary) and 100 age and sex matched controls. All cases were randomly selected from the Outpatient Clinic of Kafr El Sheikh Dermatology and Leprosy Hospital. History, clinical and microbiologic examination of the lesions were done. Vitamin C, zinc and selenium measurement were done. Zinc serum level was significantly lower in paucibacillary (PB) and multibacillary (MB) in controls (p-value<0.001)with no significant difference between paucibacillary and multibacillary patients(p-value= 0.142). Vit C serum level was also significantly lower in paucibacillary and multibacillary than in controls (p-value <0.001) and no significant difference between paucibacillary and multibacillary patients (p-value=0.066). Selenium level showed no significant difference between any of the 3 groups (p-value >0.05).  Lower serum level of Zinc and vit C in leprosy patients may be a result of disease pathogenesis or its treatment due to their consumption, being antioxidants, or might present from the start due to malnutrition that may accelerate the development of leprosy. Serum Selenium needs further studies.

Biography:

Dr. Ashok Hegde has completed his PhD from National University of Singapore, and postdoctoral studies from Institute of molecular and Cell Biology, Singapore and University of Michigan, Ann Arbor, USA. He is currently a Research Scientist at ITC Life Sciences and Technolgy Center, Bangalore, India. He has about two decades of research experience, and contributed to over fifty patents and publications. His research intereststs are in the area of skin and hair follicle biology.

Abstract:

Vitamin D is an essential micronutrient required for normal human physiology, specifically for calcium absorption, healthy skin and hair follicle growth. Natural way of Vitamin D synthesis in skin upon exposure to sunlight is in the decline due to various factors including sedentary lifestyle, indoor stay, varying food habits, religious and socioeconomic factors. It is further affected by forced indoor stays and working from home situation during these pandemic times. Vitamin D deficiency leads to various physiological conditions including bone pain, skin acne and psoriasis. Large portion of world population is deficient in Vitamin D3 and its deficiency is widely prevalent (70-100%) in Indian population as well. Oral supplementation of vitamin D3 has drawbacks of reduced absorption/bioavailability, short-half life in serum and low amounts available for metabolism. Transdermal delivery has been considered as a potent alternative to oral supplementation. Dermal delivery of novel microencapsulated Vitamin D3 may offer significant benefits in terms of enhanced bioavailability at the target sites (deep layers of skin, hair follicles and sweat pores), with decreased toxicity. Preliminary in vitro studies from our lab have shown enhanced accumulation of microencapsulated Vitamin D3 in HaCaT cells and 3D skin. Further studies are in progress to ascertain the transdermal absorption and potential bioavailability through a microencapsulated composition.

Biography:

Edileia Bagatin is the Professor, Department of Dermatology, Federal University of Sao Paulo, Brazil. 

Abstract:

Antioxidants derived from plant extracts have been extensively studied in vitro. Based in the experimental results they are proposed as beneficial oral and topical strategy to control, in vivo, the oxidative stress which is the main pathogenic factor in skin aging, particularly photoaging. However, a paucity of randomized and controlled clinical trials are available to assure the same effects. In addition, some harmful events have been reported. Regarding nutraceuticals, the bioactive peptides of collagen or hydrolyzed collagen (HC) has been suggested as an option to restore dermal collagen content. But there is no evidence about their role as preventive or therapeutic measure and when the supplementation should be initiated. In this lecture results of our in vivo studies about clinical use of oral lycopene to prevent skin damage caused by UVB and the supplementation with HC, in menopaused women, to increase dermal collagen, will be presented.

Biography:

Cynthia Edimo is a rising fourth year medical student at New York Institute of Technology College of Osteopathic Medicine. She previously attended the University of Maryland where she obtained a B.S. in Biological Sciences: Physiology and Neurobiology. Cynthia has a growing interest in Ehlers Danlos Syndrome and is continuing to learn more about it through research. She is interested in not only the dermatological aspects of this rare disease, but also the complications that this disorder casuses throughout the body. Cynthia will be pursuing an Internal Medicine residency upon graduation.

Abstract:

Ehlers-Danlos syndrome (EDS) is a group of inherited connective tissue disorders that may present with a wide range of multi-systemic complaints. Hypermobile Ehlers-Danlos syndrome (hEDS), one of the 13 identified subtypes of EDS, is the only variant without a known associated genetic mutation. Review of the literature suggests the five primary dermatological changes associated with hEDS are soft skin, atrophic cutaneous scars, piezogenic papules, hyperextensive stretchability and hematomas. Our paper will address these cutaneous manifestations and delve into how they affect patients, primarily females. Possible consequences and treatment options for these different dermatological changes as well as other skin manifestations such as livedo reticularis and elastosis perforans serpiginosa will also be further explored.

Biography:

Abstract:

Nanofat is emulsified (liquefied) and filtered fat. The fat cells have been crushed and filtered out and what remains is a liquid that contains a high concentration of stem cells. Stem cells are undifferentiated biological cells that can differentiate into specialized cells and can divide (through cell division) to produce more stem cells. Stem cells are very important in the regeneration of damaged tissues. Millifat is large parcel sized (2.4 mm and <) fat that is used when structural fat grafts are performed for deep fat compartment filling, filling of the lips, temporal regions, brows, chin, nose, and pyriform.  From last year till now we have used both nonofat & millifat in face rejuvenation simultaneously in more than 500 cases & have achieved very wonderful results. This method can be used instead of other methods of face rejuvenation & face filling due to less costs & natural components.

Biography:

Jolanta Idkowiak-Baldys has completed her PhD in Biology from Utah State University and postdoctoral studies from Medical University of South Carolina. Currently, she is a Research Fellow at Avon Products Inc Global Innovation Center where she leads Bioefficacy research group. She has published in multiple peer-reviewed journals and holds several industry patents. She has a strong expertise in skin biology, especially in the area of aging, acne, and skin disorders.

Abstract:

Non-natural, non-proteinogenic amino acids are relatively novel in the cosmetic industry. They do not become incorporated into proteins during new protein synthesis, and therefore, topical application of these molecules can lead to skin benefits. We previously showed that a novel proprietary non-proteinogenic amino acid active has significant effect on inducing epidermal turnover and hyaluronic acid production leading to clinically measured benefit on skin. To further evaluate efficacy of this ingredient, in vitro and in vivo effect on collagen production was assessed.

In vitro treatment of 3D tissue skin equivalents led to increase in pro-collagen I production. Additionally, gene expression analysis of the treated 3D tissues revealed increase expression of collagen synthesis and decrease in matrix metalloproteinases genes responsible for collagen degradation.

In vivo, treatments were evaluated in human volunteer forearms. After the treatment, biopsy samples were obtained and analyzed by histology for total collagen production as well as ratio of collagen III/I via Herovici staining. Samples were also collected non-invasively via D-squame tapes and analyzed for HSP-70 protein. HSP-70 is known to protect collagen from degradation and it was shown by us to correlate with age and wrinkle perception. Histological analysis showed increase in collagen as well as increase in collagen III/I ratio. In addition increase in collagen protecting HSP-70 was observed in skin samples.

Taken together, we showed that the novel non-proteinogenic amino acids can increase collagen production and stability, which leads to improvement in skin appearance.

Biography:

Ying Zou has completed her MD & PhD in China and postdoctoral studies from University of California San Francisco, USA. She is the director of Clinic Center of Allergic Dermatoses and vice-directer of skin & cosmetics research department, Shanghai Skin Disease Hospital, a public specilized hospital in Shanghai, China. She has published more than 30 papers in reputed journals and has been serving as a committee member of several academic societies.

Abstract:

Dermal-epidermal separation is an important basic investigation technique for pharmacology, toxicology and biology. In order to choose the optimal method for a given research need, we reviewed studies on epidermal separation. PubMed, Embase, and Web of Science were utilized. Different separation systems have been compared, including chemical, enzyme, heat and mechanical separation; each has advantages and disadvantages. Heat is simple but causes thermal damage. Chemical reagents are effective but disturb cellular electrolyte equilibrium. Enzymes provide complete separation, but destroy important components. Mechanical division does not alter physical and/or chemical integrity, but necessitates a relatively large sample and may cause cross-contamination of layers. Thus the appropriate method should be chosen for a given research question, and no single method appears superior for all purposes.

Biography:

Haytham El sayed Ali, MD,Histology department, faculty of medicine, al azhar university completed PhD  two years ago.

Abstract:

State of problem: Acne vulgaris is a common skin condition. It is characterized by a variable combination of comedones, pustules, inflammation, and scarring. NRF2 is a basic leucine zipper (bZIP) protein that produced in response to oxidative stress to induce the expression of antioxidant genes to protect against oxidative damage as well as several target genes that regulate both cell proliferation, differentiation and inflammation. The purpose of the present study is to evaluate the possible role of NRF2 in the pathogenesis of acne vulgaris. Methodology & Theoretical Orientation: Immunohistochemical localization of NRF2 in inflammatory and non inflammatory acne compared to normal skin was performed, in addition of correlating NRF2 expression with the clinical and pathological parameters of acne. The current study investigated thirty patients with acne and 30 controls. NRF2 was expressed in the acne group compared with the control group (p<0.001). This was demonstrated by higher expression positivity (perifollicular (66.7%), follicular (60%) epidermis and dermis (50%), intensity and H score in cases than in those of controls (43.3%). NRF2 was demonstrated to correlate to disease inflammation as it was upregulated in inflammatory acne than in non inflammatory (p<0.001). NRF2 expression in perifollicular and follicular epidermis was associated with early age onset p<0.001 & p=0.008 and with moderate and strong inflammatory severity p=0.006 & p=0.009 respectively. Conclusion & Significance: The upregulation of NRF2 in response to the oxidative stress could participate in acne pathogenesis through its role in both sebaceous gland and hair follicle proliferation, differentiation and through its inflammatory effect. Using of NRF2 target therapy could be beneficial in treatment of acne.

Biography:

Taghred Ahmed has completed her MB.BCH, at the age of 25 years from Menoufia University, EGYPT and passed first & second parts of Master degree of Dermatology, Andrology & STD  from Menoufia University faculty of Medicine. she is General Practitioner in Health Sector, Dermatology Resident in Berket Al Sabaa General Hospital Menoufia Governorate EGYPT, previous position General Pracitioner in health care center.

Abstract:

Abstract: Background: Acne vulgaris is a skin disease that inflames the sebaceous gland with multiple etiologic agents. Many pro-inflammatory adipokines contribute to this pathogenesis. Resistin is one of them, which acts as a pro-inflammatory mediator that activates kappa B, a nuclear factor, and c-Jun N-terminal kinases pathways inducing toll-like receptor-2, interleukin-1, 6, and Tumor Necrosis Factor  Alpha (TNF- α). The Resistin gene affects the promoter and intron regions’ polymorphisms’ expression levels.

Aim of the work: This study aims to study the association of Resistin gene polymorphisms (RETN -420 C/G) and the development of acne vulgaris in Egyptian patients and whether it is associated with serum Resistin’s levels and disease severity.

Subjects and Methods: Resistin (RETN) gene (rs1862513) genotypes were identified using the technique of Restriction Fragment Length Polymorphism (RFLP) and serum resistin presence was assessed by enzyme-linked immunosorbent assay in 40 patients suffering from acne vulgaris with 40 age- and sex-matched healthy control subjects as a cross-reference. Patients were divided into mild, moderate, and severe groups. The GAGS (Global Acne Grading System) was used to assess the severity of patients’ acne.

Results: CG and GG genotypes were immensely present in cases (P = 0.006) OR1= 4.43 CI 95% (1.53–12.7) and OR2 = 5.47 CI 95% (0.99–30.1) where G-allele statistically dominated  in the patient group where P = 0.001 and OR= 3.57 CI 95% (1.63–7.80). Also, a positive significant relationship between RETN genotypes and serum Resistin levels and GAGS score was present.

Conclusion: RETN genes rs1862513 GG and G allele are correlated to the development and severity of acne vulgaris in a sample of the Egyptian population.

Biography:

Taghreed A. El-Sayed has completed her M.B.B.Ch at the age of 25 years from Faculty of medicine – Menoufia University, Egypt. She is working resident dermatology at Egyptian ministry of health.

Abstract:

Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) were categorized as non-melanoma skin cancers. Fibulin-3 is involved in the development of different tumors; however, its role in cSCC and BCC remains unknown. we recently evaluated the role of fibulin-3 in BCC and cSCC and its relation to the available demographic, clinical and pathological data.The current study included 17 patients of BCC, 17 patients of SCC and 17age and sex matched healthy volunteer as a control group, attending to Dermatology and Plastic Surgery clinics at Menoufia University Hospital during the period between May 2019 and February 2020. We founded that Fibulin-3 expression was significantly down-regulated in cSCC and BCC tissues compared with normal skin (p1=0.018), Furthermore, there was significant difference between fibulin-3 expression in SCC and BCC groups and the degree of apoptosis (p value = 0.029 and <0.001 respectively) and between fibulin-3 intensity of expression and grade in SCC group (P value = 0.008). The results indicate that decreased fibulin-3 expression in cSCC and BCC was associated with decreased apoptosis of tumor cells thus increasing their proliferation and migration, so fibulin-3 agonist might be of benefit for cSCC and BCC patients.

Biography:

Amina Ayad had graduated from Kasr AL Ainy school of medicine,Cairo university,she is adermatologist, and she is now completing Master degree at Menoufia University. 

Abstract:

Background: Psoriasis is an immune-related disorder with dermal inflammation and epidermal hyperplasia. Cornulin (CRNN) has a significant role in keratinocyte proliferation and stimulates inflammation in psoriasis.

Aim of the Work: This work aims to evaluate CRNN’s expression values in lesional and perilesional psoriatic skin compared with the control group’s skin through immunohistochemistry.

Methods: This case–control study included 30 cases with plaque psoriasis and another 30 as controls. Patient samples were collected and immunohistochemical staining of Cornulin was conducted.

Results: In the epidermis; there was a stepwise pattern of significant Cornulin overexpression in keratinocytes starting from controls (34.00 ± 23.65) to lesional (62.59 ± 23.93) passing through perilesional skin (36.52 ± 18.49) (P < 0.001). Moreover, there was also a stepwise pattern of the significance of Cornulin starting from 4 in controls (13.3% for both) to 28 lesional cases (93.3%) and 18 (60.0%) passing through 17 perilesional skin cases (56.7%) and 5 (16.7%) (P < 0.001 for both) for inflammatory cells and adnexa, respectively.

A significant relationship between lesional epidermal Cornulin’s strong intensity and a higher H score and both hyperkeratosis and parakeratosis was found (P =0.008 for both intensity and 0.028 for both H scores).  

Conclusion: Cornulin might be implicated in keratinocyte hyperproliferation and inflammation in psoriasis vulgaris and may be valuable as targeted therapy.

Biography:

Abstract:

Hypomelanosis is a prevalent skin disorder in individuals with dark skin. Numerous inflammatory skin disorders cause hypomelanosis, even depigmentation. Its pathogenesis remains unknown, but it can be attributed to changes in melanin production in response to inflammation. The clinical manifestations, often including lesions with ill-defined borders limited to the site of inflammation, mostly appear in individuals with dark skin. The most important way to manage PIH is to effectively treat the underlying skin disorder that has led to it, however, medical therapy and phototherapy can be helpful, as well.

Biography:

Marwa Said Mahmoud has completed her MD at the age of  36 years from AL-Azhar University and postdoctoral studies from  boston University School of Medicine.  She is the  President of dermoscopy unit in dermatology departement, She has published more than 25 papers in  Dermatology journals and has been serving as an editorial board member of  international dermoscopy society.

Abstract:

Neonatal skin diseases are very important, some of those diseases can be easily diagnosed by clinical morphology however some cases are difficult .

Dermoscopy as noninvasive child friendly office technique that can use as diagnostic or prognostic instrument without causing fear or pain.

Neonatal disease categories :

Birthmarks (e.g: haemangiomas, port-wine stains, melanocytic navi),

Inflammatory conditions  (e.g: eczema, psoriasis),

Infectious skin diseases (e.g: scabies and molluscum contagiosum),

Neonatal hair problems.

Biography:

Abstract:

Background:

Topical exposure to plant-derived substances may cause a phototoxic reaction termed phytophotodermatitis. Phytophotodermatitis occurs most commonly after exposure to limes and other plants. The aim of this study is to determine the incidence of severe phytophotodermatitis in admitted patients during 2018 in the dermatology department of Herat Hospital

Methodology:

This descriptive case series study was done in the Dermatology Department of Herat Regional Hospital from April – June 2018. We admitted 17 cases for acute severe photodamaged due to eatable plant names (Shorak) the original name of which is (Salsa Rigid). The data was collected through a designed form and all the information was collected from patients' files. EPI info 7 was used for data analyzes and the patients' photos were taken when appropriate

Result :

Out of 17 patients, 5 (29.4%) were men, and 12 (70.6%) women. 6 (35.2%) of patients were from Herat Province, and the rest 11(64.8%) from Badghis. Both Herat and Badghis patients were all from the districts and rural areas. The age ranged from 2-56 years with an average of 22 years. The hospital staying time was between 1 – 17 days with an average length of stay of 5.9 days. The face was involved in all patients (100%), hands, feet, and necks affected by 64.7%, 53%, and 5.3% respectively.

Conclusion:

Even though phytophotodermatitis in particularly severe form is rare in other countries, it is still highly prevalent in our community leading to lifelong, disfiguring, and disabilities. Hence, Strong efforts by policy-makers are required to deal with this public health challenge.

Biography:

Dr. Ola Bakry has completed her PhD in 2010 from Menoufiya Faculty of Medicine. She is working as an assisstant professor of Dermatology and Andrology in Menoufiya Faculty of Medicine. She has published more than 70 papers in reputed journals in the fields of Clinical Dermatology, Dermatopathology and Aesthetic Medicine. She is a reviewer and editorial board member of many international journals.

Abstract:

Alopecia areata (AA) is a common dermatologic disease with autoimmune etiology. Systemic and tissue oxidative stress are present in AA. Nuclear factor-E2-related factor 2 (Nrf2) is a transcription factor which stimulates transcription of antioxidant genes. The current work aimed to investigate the role of Nrf2 in systemic oxidative stress in AA. Thirty cases with AA and 30 age and gender matched healthy subjects were included. Cases were diagnosed clinically and by dermoscopy and evaluated according to severity of alopecia tool (SALT) score. Nrf2, total oxidant capacity and total antioxidant capacity were measured by enzyme linked immunosorbent assay (ELISA). Oxidative stress index was then calculated. Serum Nrf2 and total antioxidant capacity were significantly lower in AA than control group (P<0.001 for both), while total oxidant capacity and oxidative stress index were significantly higher in AA than control group (P<0.001 for both). There was a significant negative correlation between total antioxidant capacity and age (r= -0.5, P= 0.004). High Nrf2 serum level was significantly associated with positive hair pull test (86.7%) while low Nrf2 was significantly associated with alopecia totalis (P = 0.02 for both). There was significant positive correlation between NRF2 and total antioxidant capacity (r= 0.43, P= 0.01) and significant negative correlation between NRF2 and total oxidant capacity (r= -0.44, P= 0.01) and between NRF2 and oxidative stress index (r= -0.46, P =0.01). Therefore, Nrf2 is lower in AA than control indicating that systemic oxidative stress may be, at least in part, due to low Nrf2. The association between low Nrf2 and alopecia totalis compared with patchy alopecia may be due to destruction of Nrf2 by high oxidative stress in totalis variant. The use of Nrf2 activators may be beneficial in severe, resistant or recurrent cases.

Biography:

She completed doctoral studies at the Faculty of Chemistry at the University of Adam Mickiewicza in PoznaÅ„, where she obtained the title of doctor of chemical sciences. A graduate of master's and engineering studies at the Faculty of Chemical Technology of the PoznaÅ„ University of Technology. A graduate of postgraduate studies in cosmetic and cosmeceutical chemistry at the University of Adam Mickiewicz in PoznaÅ„. Lecturer at the Medical University of PoznaÅ„ and the University of Education and Therapy in PoznaÅ„. He works at the Symbiosis Laboratory in the PoznaÅ„ Nakowo - Technological Park as a technologist. She is responsible for testing the quality of cosmetic formulas. She participated in many national and foreign congresses in the field of cosmetic chemistry, as well as courses and specialist training, including in the field of "Analyst - diagnostics in the field of trichology. Trichological training ”. For many years he has been dealing with the practical applications of cosmetic chemistry in the Beauty industry.

Abstract:

Extreme indoor and outdoor conditions in patients’ places of stay (hot or cold air and changes in humidity) lead to weakening of the lipid barrier function and disproportionate epidermal microflora, which results in a lower threshold of physical and chemical tolerance of the skin manifesting as erythema, burning, dryness and deterioration of skin condition. Chronic epidermal irritation caused by the above factors leads to discomfort and prevents the proper functioning of the skin, as it results in thickening of the epidermis, widening of the sebaceous glands and pigmentation disorders. Regenerative mechanisms preventing lipid peroxidation or carbonylation of skin cell proteins, including epidermis, are focused on restoring physiology and not on "fibroblast protection", which can accelerate the loss of firmness. Taking into account the theory of free radical or telomeric aging, it may be stated that the skin exposed to extreme conditions ages faster. When faced with such a problem, it seems pointless to apply invasive rejuvenating treatments without prior diagnosis or acquiring basic knowledge of care and hygiene of the epidermis.

Daily skin care and cosmetics play a key role in the anti-aging process. Hygiene and proper cosmetic habits are essential for health and youthful appearance of the skin. Appropriate regulatory exfoliation, or the so-called turnover of the epidermis, should be used so as not to generate excessive free radical stress. Antioxidants are necessary for this. Modern products based on a liquid crystal base compatible with the liquid crystal structure of epidermal cement together with active emollients allow for restoration of appropriate epidermis parameters. The method of exfoliation with selected ingredients enables long-term skin cleansing by accelerating the turnover of the epidermis without excessive free radical stress, drying and irritation.